Ontology highlight
ABSTRACT:
SUBMITTER: Keller AN
PROVIDER: S-EPMC5052618 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Keller Andrew N AN Xin Yue Y Boer Stephanie S Reinhardt Jonathan J Baker Rachel R Arciszewska Lidia K LK Lewis Peter J PJ Sherratt David J DJ Löwe Jan J Grainge Ian I
Scientific reports 20161006
Bacterial chromosomes are most often circular DNA molecules. This can produce a topological problem; a genetic crossover from homologous recombination results in dimerization of the chromosome. A chromosome dimer is lethal unless resolved. A site-specific recombination system catalyses this dimer-resolution reaction at the chromosomal site dif. In Escherichia coli, two tyrosine-family recombinases, XerC and XerD, bind to dif and carry out two pairs of sequential strand exchange reactions. Howeve ...[more]