Ontology highlight
ABSTRACT:
SUBMITTER: Pereira M
PROVIDER: S-EPMC5052644 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Pereira Milton M Tourlomousis Panagiotis P Wright John J P Monie Tom T Bryant Clare E CE
Nature communications 20160927
Interleukin-1β (IL-1β) is a proinflammatory cytokine required for host control of bacterial infections, and its production must be tightly regulated to prevent excessive inflammation. Here we show that caspase recruitment domain-containing protein 9 (CARD9), a protein associated with induction of proinflammatory cytokines by fungi, has a negative role on IL-1β production during bacterial infection. Specifically, in response to activation of the nucleotide oligomerization domain receptor pyrin-do ...[more]