Ontology highlight
ABSTRACT:
SUBMITTER: Chen SG
PROVIDER: S-EPMC5052651 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Chen Shu G SG Stribinskis Vilius V Rane Madhavi J MJ Demuth Donald R DR Gozal Evelyne E Roberts Andrew M AM Jagadapillai Rekha R Liu Ruolan R Choe Kyonghwan K Shivakumar Bhooma B Son Francheska F Jin Shunying S Kerber Richard R Adame Anthony A Masliah Eliezer E Friedland Robert P RP
Scientific reports 20161006
Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-like transmission of protein aggregation. Factors responsible for the initiation of AS aggregation are unknown. To evaluate the role of amyloid proteins made by the microbiota we exposed aged rats and transgenic C. elegans to E. coli producing the extracellular bacterial amyloid protein curli. Rats exposed to curli-producing bacteria displayed increased neuronal AS deposition in both gut and brain and enha ...[more]