Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) have recently received wide attention as key molecules that mediate a variety of physiological and pathological processes by regulating gene expression; however, knowledge of lncRNAs in rheumatoid arthritis (RA) is limited. Thus, we investigated the lncRNA expression profile in fibroblast-like synoviocytes (FLSs) from patients with RA and explored the function of abundantly expressed lncRNAs.

Methods

LncRNA and mRNA microarrays were performed to identify differentially expressed lncRNAs in RA FLSs compared with normal FLSs. Quantitative polymerase chain reaction (qPCR) was used to validate the results, and correlation analysis was used to analyze the relationship between these aberrantly expressed lncRNAs and clinical characteristics.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5053204 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature