Ontology highlight
ABSTRACT:
SUBMITTER: Frampton M
PROVIDER: S-EPMC5053363 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Frampton Matthew M da Silva Filho Miguel Inacio MI Broderick Peter P Thomsen Hauke H Försti Asta A Vijayakrishnan Jayaram J Cooke Rosie R Enciso-Mora Victor V Hoffmann Per P Nöthen Markus M MM Lloyd Amy A Holroyd Amy A Eisele Lewin L Jöckel Karl-Heinz KH Ponader Sabine S von Strandmann Elke Pogge EP Lightfoot Tracy T Roman Eve E Lake Annette A Montgomery Dorothy D Jarrett Ruth F RF Swerdlow Anthony J AJ Engert Andreas A Hemminki Kari K Houlston Richard S RS
Nature communications 20130101
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10(-12), odd ...[more]