Transformation by different oncogenes relies on specific metabolic adaptations.
Ontology highlight
ABSTRACT:
SUBMITTER: Peruzzo P
PROVIDER: S-EPMC5053564 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Transformation by different oncogenes relies on specific metabolic adaptations.
Peruzzo Paolo P Comelli Marina M Di Giorgio Eros E Franforte Elisa E Mavelli Irene I Brancolini Claudio C
Cell cycle (Georgetown, Tex.) 20160802 19
Metabolic adaptations are emerging as common traits of cancer cells and tumor progression. In vitro transformation of NIH 3T3 cells allows the analysis of the metabolic changes triggered by a single oncogene. In this work, we have compared the metabolic changes induced by H-RAS and by the nuclear resident mutant of histone deacetylase 4 (HDAC4). RAS-transformed cells exhibit a dominant aerobic glycolytic phenotype characterized by up-regulation of glycolytic enzymes, reduced oxygen consumption a ...[more]
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