Ontology highlight
ABSTRACT:
SUBMITTER: Pu Y
PROVIDER: S-EPMC5053736 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Pu Youguang Y Zhao Fangfang F Wang Haiyan H Cai Wenjing W Gao Jin J Li Yinpeng Y Cai Shanbao S
Oncotarget 20160501 19
An association has been reported between miR-34a-5p and several types of cancer. Specifically, in this study, using systematic observations of multi-drug sensitive (G-292 and MG63.2) and resistant (SJSA-1 and MNNG/HOS) osteosarcoma (OS) cell lines, we showed that miR-34a-5p promotes the multi-drug resistance of OS through the receptor tyrosine kinase CD117, a direct target of miR-34a-5p. Consistently, the siRNA-mediated repression of CD117 in G-292 and MG63.2 cells led to a similar phenotype tha ...[more]