Ontology highlight
ABSTRACT:
SUBMITTER: Seo E
PROVIDER: S-EPMC5053763 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Seo Eunjeong E Basu-Roy Upal U Gunaratne Preethi H PH Coarfa Cristian C Lim Dae-Sik DS Basilico Claudio C Mansukhani Alka A
Cell reports 20130620 6
The osteoblastic and adipocytic lineages arise from mesenchymal stem cells (MSCs), but few regulators of self-renewal and early cell-fate decisions are known. Here, we show that the Hippo pathway effector YAP1 is a direct target of SOX2 and can compensate for the self-renewal defect caused by SOX2 inactivation in osteoprogenitors and MSCs. Osteogenesis is blocked by high SOX2 or YAP1, accelerated by depletion of either one, and the inhibition of osteogenesis by SOX2 requires YAP1. SOX2 favors ad ...[more]