Ontology highlight
ABSTRACT: Key messages
• Hepatic stellate cells (HSCs) are an important pharmacological target for the prevention of nonalcoholic fatty liver diseases (NAFLD). • Retinoids and retinoic acid receptors (RARs) possess favorable metabolic modulating properties. • We show that an agonist for retinoic acid receptor-β2 (RARβ2), but not RARγ, mitigates HSC activation and NAFLD.
SUBMITTER: Trasino SE
PROVIDER: S-EPMC5053866 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Trasino Steven E SE Tang Xiao-Han XH Jessurun Jose J Gudas Lorraine J LJ
Journal of molecular medicine (Berlin, Germany) 20160606 10
Hepatic stellate cells (HSCs) are an important cellular target for the development of novel pharmacological therapies to prevent and treat nonalcoholic fatty liver diseases (NAFLD). Using a high fat diet (HFD) model of NAFLD, we sought to determine if synthetic selective agonists for retinoic acid receptor β2 (RARβ2) and RARγ can mitigate HSC activation and HSC relevant signaling pathways during early stages of NAFLD, before the onset of liver injury. We demonstrate that the highly selective RAR ...[more]