Ontology highlight
ABSTRACT:
SUBMITTER: Soniat M
PROVIDER: S-EPMC5053885 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Soniat Michael M Chook Yuh Min YM
Structure (London, England : 1993) 20160908 10
Karyopherin-β2 or Transportin-1 binds proline-tyrosine nuclear localization signals (PY-NLSs) in its cargos. PY-NLSs are described by structural disorder, overall positive charge, and binding epitopes composed of an N-terminal hydrophobic or basic motif and a C-terminal R-X<sub>2-5</sub>P-Y motif. The N-terminal tail of histone H3 binds Kapβ2 with high affinity but does not contain a recognizable PY-NLS. The crystal structure of the Kapβ2-H3 tail shows residues 11-27 of H3 binding to the PY-NLS ...[more]