Ontology highlight
ABSTRACT:
SUBMITTER: Brandao MM
PROVIDER: S-EPMC5054073 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Brandão Marcelo M MM Silva-Brandão Karina L KL Costa Fernando F FF Saad Sara T O ST
Genomics, proteomics & bioinformatics 20060801 3
Proteins containing an Rho GTPase-activating protein (RhoGAP) domain work as molecular switches involved in the regulation of diverse cellular functions. The ability of these GTPases to regulate a wide number of cellular processes conies from their interactions with multiple effectors and inhibitors, including the RhoGAP family, which stimulates their intrinsic GTPase activity. Here, a phylogenetic approach was applied to study the evolutionary relationship among 59 RhoGAP domain-containing prot ...[more]