Ontology highlight
ABSTRACT:
SUBMITTER: Zamboni V
PROVIDER: S-EPMC5054378 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Zamboni Valentina V Armentano Maria M Sarò Gabriella G Ciraolo Elisa E Ghigo Alessandra A Germena Giulia G Umbach Alessandro A Valnegri Pamela P Passafaro Maria M Carabelli Valentina V Gavello Daniela D Bianchi Veronica V D'Adamo Patrizia P de Curtis Ivan I El-Assawi Nadia N Mauro Alessandro A Priano Lorenzo L Ferri Nicola N Hirsch Emilio E Merlo Giorgio R GR
Scientific reports 20161007
During brain development, the small GTPases Rac1/Rac3 play key roles in neuronal migration, neuritogenesis, synaptic formation and plasticity, via control of actin cytoskeleton dynamic. Their activity is positively and negatively regulated by GEFs and GAPs molecules, respectively. However their in vivo roles are poorly known. The ArhGAP15 gene, coding for a Rac-specific GAP protein, is expressed in both excitatory and inhibitory neurons of the adult hippocampus, and its loss results in the hyper ...[more]