Ontology highlight
ABSTRACT:
SUBMITTER: Kakkar V
PROVIDER: S-EPMC5054386 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Kakkar Vaishali V Kuiper E F Elsiena EF Pandey Abhinav A Braakman Ineke I Kampinga Harm H HH
Scientific reports 20161007
Parkinson's disease is one of the most common neurodegenerative disorders and several mutations in different genes have been identified to contribute to the disease. A loss of function parkin RING1 domain mutant (C289G) is associated with autosomal-recessive juvenile-onset Parkinsonism (AR-JP) and displays altered solubility and sequesters into aggregates. Single overexpression of almost each individual member of the Hsp40 (DNAJ) family of chaperones efficiently reduces parkin C289G aggregation ...[more]