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Use of aerosol route to fabricate positively charged Au/Fe₃O₄ Janus nanoparticles as multifunctional nanoplatforms.

ABSTRACT: Gold (Au)-decorated iron oxide (Fe₃O₄), Au/Fe₃O₄, Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe₃O₄ domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities were tested in computed tomography (CT) and magnetic resonance (MR) imaging, gene-delivery and photothermal therapy. No additional polymeric coatings of the Janus particles also had a unique ability to suppress inflammatory responses in macrophages challenged with lipopolysaccharide, which may be due to the absence of amine groups.

SUBMITTER: Byeon JH

PROVIDER: S-EPMC5054399 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Use of aerosol route to fabricate positively charged Au/Fe3O4 Janus nanoparticles as multifunctional nanoplatforms.

Byeon Jeong Hoon JH Park Jae Hong JH

Scientific reports 20161007

Gold (Au)-decorated iron oxide (Fe3O4), Au/Fe3O4, Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe3O4 domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities were tested in computed tomography (CT) and magnetic resonance (MR) ...[more]

PMID: 27713519

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