Ontology highlight
ABSTRACT:
SUBMITTER: Boel G
PROVIDER: S-EPMC5054687 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Boël Grégory G Letso Reka R Neely Helen H Price W Nicholson WN Wong Kam-Ho KH Su Min M Luff Jon J Valecha Mayank M Everett John K JK Acton Thomas B TB Xiao Rong R Montelione Gaetano T GT Aalberts Daniel P DP Hunt John F JF
Nature 20160113 7586
Degeneracy in the genetic code, which enables a single protein to be encoded by a multitude of synonymous gene sequences, has an important role in regulating protein expression, but substantial uncertainty exists concerning the details of this phenomenon. Here we analyse the sequence features influencing protein expression levels in 6,348 experiments using bacteriophage T7 polymerase to synthesize messenger RNA in Escherichia coli. Logistic regression yields a new codon-influence metric that cor ...[more]