Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.
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ABSTRACT:
SUBMITTER: Qiu B
PROVIDER: S-EPMC5055068 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.
Qiu Bin B Bell Richard L RL Cao Yong Y Zhang Lingling L Stewart Robert B RB Graves Tamara T Lumeng Lawrence L Yong Weidong W Liang Tiebing T
Journal of genetics and genomics = Yi chuan xue bao 20160429 7
Neuropeptide Y (NPY) is widely expressed in the central nervous system and influences many physiological processes. It is located within the rat quantitative trait locus (QTL) for alcohol preference on chromosome 4. Alcohol-nonpreferring (NP) rats consume very little alcohol, but have significantly higher NPY expression in the brain than alcohol-preferring (P) rats. We capitalized on this phenotypic difference by creating an Npy knockout (KO) rat using the inbred NP background to evaluate NPY ef ...[more]
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