Ontology highlight
ABSTRACT:
SUBMITTER: Mundalil Vasu M
PROVIDER: S-EPMC5055328 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Mundalil Vasu Mahesh M Anitha Ayyappan A Takahashi Taro T Thanseem Ismail I Iwata Keiko K Asakawa Tetsuya T Suzuki Katsuaki K
PloS one 20161007 10
Evidence suggests neuroprotective effects of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on the developed neurons in the adult brain. In contrast, the drug may be deleterious to immature or undifferentiated neural cells, although the mechanism is unclear. Recent investigations have suggested that microRNAs (miRNA) may be critical for effectiveness of psychotropic drugs including SSRI. We investigated whether fluoxetine could modulate expressions of neurologically relevant miRNAs ...[more]