Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5055352 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity.
Wang Lianmei L Zhang Hongbing H Li Chunying C Yi Yan Y Liu Jing J Zhao Yong Y Tian Jingzhuo J Zhang Yushi Y Wei Xiaolu X Gao Yue Y Liang Aihua A
PloS one 20161007 10
Aristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity. We found that OM reduced mouse mortality caused by AMK and attenuated AMK-induced acute nephrotoxicity in rats. OM enhanced hepatic Cyp 1a1/2 and renal Cyp 1a1 expression in rats, as well as CYP 1A1 expression in human renal tubular epithelial cells ...[more]
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