Ontology highlight
ABSTRACT:
SUBMITTER: Shimizu K
PROVIDER: S-EPMC5056436 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nature communications 20160930
Learning and memory depend on the time of day in various organisms, but it is not clear whether and how the circadian clock regulates memory performance. Here we show that consolidation of long-term recognition memory is a circadian-regulated process, which is blunted by disruption of the hippocampal clock. We focused on SCOP, a key molecule regulating hippocampus-dependent long-term memory for objects. The amounts of SCOP and its binding partner K-Ras in the hippocampal membrane rafts exhibit r ...[more]