Thresholds for Arterial Wall Inflammation Quantified by ¹⁸F-FDG PET Imaging: Implications for Vascular Interventional Studies.

ABSTRACT:

Objectives

This study assessed 5 frequently applied arterial ¹⁸fluorodeoxyglucose (¹⁸F-FDG) uptake metrics in healthy control subjects, those with risk factors and patients with cardiovascular disease (CVD), to derive uptake thresholds in each subject group. Additionally, we tested the reproducibility of these measures and produced recommended sample sizes for interventional drug studies.

Background

¹⁸F-FDG positron emission tomography (PET) can identify plaque inflammation as a surrogate endpoint for vascular interventional drug trials. However, an overview of ¹⁸F-FDG uptake metrics, threshold values, and reproducibility in healthy compared with diseased subjects is not available.

Methods

¹⁸F-FDG PET/CT of the ca

SUBMITTER: van der Valk FM 

PROVIDER: S-EPMC5056585 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature