Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
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ABSTRACT:
SUBMITTER: Surendran P
PROVIDER: S-EPMC5056636 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Surendran Praveen P Drenos Fotios F Young Robin R Warren Helen H Cook James P JP Manning Alisa K AK Grarup Niels N Sim Xueling X Barnes Daniel R DR Witkowska Kate K Staley James R JR Tragante Vinicius V Tukiainen Taru T Yaghootkar Hanieh H Masca Nicholas N Freitag Daniel F DF Ferreira Teresa T Giannakopoulou Olga O Tinker Andrew A Harakalova Magdalena M Mihailov Evelin E Liu Chunyu C Kraja Aldi T AT Fallgaard Nielsen Sune S Rasheed Asif A Samuel Maria M Zhao Wei W Bonnycastle Lori L LL Jackson Anne U AU Narisu Narisu N Swift Amy J AJ Southam Lorraine L Marten Jonathan J Huyghe Jeroen R JR Stančáková Alena A Fava Cristiano C Ohlsson Therese T Matchan Angela A Stirrups Kathleen E KE Bork-Jensen Jette J Gjesing Anette P AP Kontto Jukka J Perola Markus M Shaw-Hawkins Susan S Havulinna Aki S AS Zhang He H Donnelly Louise A LA Groves Christopher J CJ Rayner N William NW Neville Matt J MJ Robertson Neil R NR Yiorkas Andrianos M AM Herzig Karl-Heinz KH Kajantie Eero E Zhang Weihua W Willems Sara M SM Lannfelt Lars L Malerba Giovanni G Soranzo Nicole N Trabetti Elisabetta E Verweij Niek N Evangelou Evangelos E Moayyeri Alireza A Vergnaud Anne-Claire AC Nelson Christopher P CP Poveda Alaitz A Varga Tibor V TV Caslake Muriel M de Craen Anton Jm AJ Trompet Stella S Luan Jian'an J Scott Robert A RA Harris Sarah E SE Liewald David Cm DC Marioni Riccardo R Menni Cristina C Farmaki Aliki-Eleni AE Hallmans Göran G Renström Frida F Huffman Jennifer E JE Hassinen Maija M Burgess Stephen S Vasan Ramachandran S RS Felix Janine F JF Uria-Nickelsen Maria M Malarstig Anders A Reily Dermot F DF Hoek Maarten M Vogt Thomas T Lin Honghuang H Lieb Wolfgang W Traylor Matthew M Markus Hugh F HF Highland Heather M HM Justice Anne E AE Marouli Eirini E Lindström Jaana J Uusitupa Matti M Komulainen Pirjo P Lakka Timo A TA Rauramaa Rainer R Polasek Ozren O Rudan Igor I Rolandsson Olov O Franks Paul W PW Dedoussis George G Spector Timothy D TD Jousilahti Pekka P Männistö Satu S Deary Ian J IJ Starr John M JM Langenberg Claudia C Wareham Nick J NJ Brown Morris J MJ Dominiczak Anna F AF Connell John M JM Jukema J Wouter JW Sattar Naveed N Ford Ian I Packard Chris J CJ Esko Tõnu T Mägi Reedik R Metspalu Andres A de Boer Rudolf A RA van der Meer Peter P van der Harst Pim P Gambaro Giovanni G Ingelsson Erik E Lind Lars L de Bakker Paul Iw PI Numans Mattijs E ME Brandslund Ivan I Christensen Cramer C Petersen Eva Rb ER Korpi-Hyövälti Eeva E Oksa Heikki H Chambers John C JC Kooner Jaspal S JS Blakemore Alexandra If AI Franks Steve S Jarvelin Marjo-Riitta MR Husemoen Lise L LL Linneberg Allan A Skaaby Tea T Thuesen Betina B Karpe Fredrik F Tuomilehto Jaakko J Doney Alex Sf AS Morris Andrew D AD Palmer Colin Na CN Holmen Oddgeir Lingaas OL Hveem Kristian K Willer Cristen J CJ Tuomi Tiinamaija T Groop Leif L Käräjämäki AnneMari A Palotie Aarno A Ripatti Samuli S Salomaa Veikko V Alam Dewan S DS Shafi Majumder Abdulla Al AA Di Angelantonio Emanuele E Chowdhury Rajiv R McCarthy Mark I MI Poulter Neil N Stanton Alice V AV Sever Peter P Amouyel Philippe P Arveiler Dominique D Blankenberg Stefan S Ferrières Jean J Kee Frank F Kuulasmaa Kari K Müller-Nurasyid Martina M Veronesi Giovanni G Virtamo Jarmo J Deloukas Panos P Elliott Paul P Zeggini Eleftheria E Kathiresan Sekar S Melander Olle O Kuusisto Johanna J Laakso Markku M Padmanabhan Sandosh S Porteous David D Hayward Caroline C Scotland Generation G Collins Francis S FS Mohlke Karen L KL Hansen Torben T Pedersen Oluf O Boehnke Michael M Stringham Heather M HM Frossard Philippe P Newton-Cheh Christopher C Tobin Martin D MD Nordestgaard Børge Grønne BG Caulfield Mark J MJ Mahajan Anubha A Morris Andrew P AP Tomaszewski Maciej M Samani Nilesh J NJ Saleheen Danish D Asselbergs Folkert W FW Lindgren Cecilia M CM Danesh John J Wain Louise V LV Butterworth Adam S AS Howson Joanna Mm JM Munroe Patricia B PB
Nature genetics 20160912 10
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare miss ...[more]