Ontology highlight
ABSTRACT:
SUBMITTER: Tan BS
PROVIDER: S-EPMC5056717 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Tan Boon Siang Nicholas BS Kwek Joly J Wong Chong Kum Edwin CK Saner Nicholas J NJ Yap Charlotte C Felquer Fernando F Morris Michael B MB Gardner David K DK Rathjen Peter D PD Rathjen Joy J
PloS one 20161010 10
Multiple pluripotent cell populations, which together comprise the pluripotent cell lineage, have been identified. The mechanisms that control the progression between these populations are still poorly understood. The formation of early primitive ectoderm-like (EPL) cells from mouse embryonic stem (mES) cells provides a model to understand how one such transition is regulated. EPL cells form from mES cells in response to l-proline uptake through the transporter Slc38a2. Using inhibitors of cell ...[more]