Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79.
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ABSTRACT:
SUBMITTER: Bowen CD
PROVIDER: S-EPMC5056906 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
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Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79.
Bowen Christopher D CD Renner Daniel W DW Shreve Jacob T JT Tafuri Yolanda Y Payne Kimberly M KM Dix Richard D RD Kinchington Paul R PR Gatherer Derek D Szpara Moriah L ML
Virology 20160321
Herpes simplex virus 1 (HSV-1) is a widespread global pathogen, of which the strain KOS is one of the most extensively studied. Previous sequence studies revealed that KOS does not cluster with other strains of North American geographic origin, but instead clustered with Asian strains. We sequenced a historical isolate of the original KOS strain, called KOS63, along with a separately isolated strain attributed to the same source individual, termed KOS79. Genomic analyses revealed that KOS63 clos ...[more]
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