Ontology highlight
ABSTRACT:
SUBMITTER: Marquard J
PROVIDER: S-EPMC5057326 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Marquard J J Stirban A A Schliess F F Sievers F F Welters A A Otter S S Fischer A A Wnendt S S Meissner T T Heise T T Lammert E E
Diabetes, obesity & metabolism 20151026 1
In this clinical trial, we investigated the blood glucose (BG)-lowering effects of 30, 60 and 90 mg dextromethorphan (DXM) as well as 100 mg sitagliptin alone versus combinations of DXM and sitagliptin during an oral glucose tolerance test (OGTT) in 20 men with T2DM. The combination of 60 mg DXM plus 100 mg sitagliptin was observed to have the strongest effect in the OGTT. It lowered maximum BG concentrations and increased the baseline-adjusted area under the curve for serum insulin concentratio ...[more]