Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions.
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ABSTRACT:
SUBMITTER: Friciu M
PROVIDER: S-EPMC5058506 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions.
Friciu Mihaela M Zaraa Sarra S Roullin V Gaëlle VG Leclair Grégoire G
PloS one 20161011 10
The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentr ...[more]
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