Ontology highlight
ABSTRACT:
SUBMITTER: Apgar JR
PROVIDER: S-EPMC5058614 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Apgar James R JR Mader Michelle M Agostinelli Rita R Benard Susan S Bialek Peter P Johnson Mark M Gao Yijie Y Krebs Mark M Owens Jane J Parris Kevin K St Andre Michael M Svenson Kris K Morris Carl C Tchistiakova Lioudmila L
mAbs 20160913 7
Antibodies are an important class of biotherapeutics that offer specificity to their antigen, long half-life, effector function interaction and good manufacturability. The immunogenicity of non-human-derived antibodies, which can be a major limitation to development, has been partially overcome by humanization through complementarity-determining region (CDR) grafting onto human acceptor frameworks. The retention of foreign content in the CDR regions, however, is still a potential immunogenic lia ...[more]