Ontology highlight
ABSTRACT:
SUBMITTER: Agostini M
PROVIDER: S-EPMC5058650 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Agostini Massimiliano M Annicchiarico-Petruzzelli Margherita M Melino Gerry G Rufini Alessandro A
Oncotarget 20160501 21
Reactive oxygen species are involved in both physiological and pathological processes including neurodegeneration and cancer. Therefore, cells have developed scavenging mechanisms to maintain redox homeostasis under control. Tumor suppressor genes play a critical role in the regulation of antioxidant genes. Here, we investigated whether the tumor suppressor gene TAp73 is involved in the regulation of metabolic adaptations triggered in response to oxidative stress. H2O2 treatment resulted in nume ...[more]