Ontology highlight
ABSTRACT:
SUBMITTER: Fiorentino FP
PROVIDER: S-EPMC5058735 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Fiorentino Francesco Paolo FP Tokgün Elvan E Solé-Sánchez Sònia S Giampaolo Sabrina S Tokgün Onur O Jauset Toni T Kohno Takashi T Perucho Manuel M Soucek Laura L Yokota Jun J
Oncotarget 20160501 21
Small cell lung cancer (SCLC) is the most aggressive type of lung cancer with high mortality. One of the MYC family genes, MYC, MYCL or MYCN, is amplified in ~20% of the SCLCs; therefore, MYC proteins are potential therapeutic targets in SCLC patients. We investigated the therapeutic impact of Omomyc, a MYC dominant negative, in a panel of SCLC cell lines. Strikingly, Omomyc suppressed the growth of all tested cell lines by inducing cell cycle arrest and/or apoptosis. Induction of G1 arrest by O ...[more]