Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC5058770 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Li Mianyang M Gao Li L Li Zhenling Z Sun Junzhong J Zhang Hui H Duan Haoqing H Ma Yigai Y Wang Chengbin C
Oncotarget 20160501 21
The aim of this study is to evaluate the frequency of CTNNA1 hypermethylation in acute myeloid leukemia (AML) patients in an attempt to improve molecular prognostic model. CTNNA1 promoter methylation levels in 319 newly diagnosed AML patients were detected using quantitative methylation-specific polymerase chain reaction (qMS-PCR). Furthermore, hematological characteristics, cytogenetic abnormalities, and genetic mutation status were analyzed, followed by assessment of clinical impact. Our findi ...[more]