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Validation of DAB2IP methylation and its relative significance in predicting outcome in renal cell carcinoma.


ABSTRACT: We have recently reported tumor suppressive role of DAB2IP in RCC development. In this study, We identified one CpG methylation biomarker (DAB2IP CpG1) located UTSS of DAB2IP that was associated with poor overall survival in a cohort of 318 ccRCC patients from the Cancer Genome Atlas (TCGA). We further validated the prognostic accuracy of DAB2IP CpG methylation by pyrosequencing quantitative methylation assay in 224 ccRCC patients from multiple Chinese centers (MCHC set), and 239 patients from University of Texas Southwestern Medical Center at Dallas (UTSW set) by using FFPE samples. DAB2IP CpG1 can predict the overall survival of patients in TCGA, MCHC, and UTSW sets independent of patient age, Fuhrman grade and TNM stage (all p<0.05). DAB2IP CpG1 successfully categorized patients into high-risk and low-risk groups with significant differences of clinical outcome in respective clinical subsets, regardless of age, sex, grade, stage, or race (HR: 1.63-7.83; all p<0.05). The detection of DAB2IP CpG1 methylation was minimally affected by ITH in ccRCC. DAB2IP mRNA expression was regulated by DNA methylation in vitro. DAB2IP CpG1 methylation is a practical and repeatable biomarker for ccRCC, which can provide prognostic value that complements the current staging system.

SUBMITTER: Wang ZR 

PROVIDER: S-EPMC5058774 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Validation of DAB2IP methylation and its relative significance in predicting outcome in renal cell carcinoma.

Wang Zong-Ren ZR   Wei Jin-Huan JH   Zhou Jian-Cheng JC   Haddad Ahmed A   Zhao Liang-Yun LY   Kapur Payal P   Wu Kai-Jie KJ   Wang Bin B   Yu Yan-Hong YH   Liao Bing B   He Da-Lin DL   Chen Wei W   Margulis Vitaly V   Hsieh Jer-Tsong JT   Luo Jun-Hang JH  

Oncotarget 20160501 21


We have recently reported tumor suppressive role of DAB2IP in RCC development. In this study, We identified one CpG methylation biomarker (DAB2IP CpG1) located UTSS of DAB2IP that was associated with poor overall survival in a cohort of 318 ccRCC patients from the Cancer Genome Atlas (TCGA). We further validated the prognostic accuracy of DAB2IP CpG methylation by pyrosequencing quantitative methylation assay in 224 ccRCC patients from multiple Chinese centers (MCHC set), and 239 patients from U  ...[more]

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