Ontology highlight
ABSTRACT:
SUBMITTER: Yekkirala AS
PROVIDER: S-EPMC5060010 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Yekkirala Ajay S AS Kalyuzhny Alexander E AE Portoghese Philip S PS
ACS chemical biology 20130517 7
Bivalent ligands that contain two pharmacophores linked by a spacer are promising tools to investigate the pharmacology of opioid receptor heteromers. Evidence for occupation of neighboring protomers by two phamacophores of a single bivalent ligand (bridging) has relied mainly on pharmacological data. In the present study, we have employed an immunocytochemical correlate to support in vivo biological studies that are consistent with bridging. We show that a bivalent mu agonist/delta antagonist ( ...[more]