Ontology highlight
ABSTRACT:
SUBMITTER: Imai S
PROVIDER: S-EPMC5061125 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Imai Shunsuke S Kumar Parimal P Hellen Christopher U T CU D'Souza Victoria M VM Wagner Gerhard G
Nature structural & molecular biology 20160815 9
Many viruses bypass canonical cap-dependent translation in host cells by using internal ribosomal entry sites (IRESs) in their transcripts; IRESs hijack initiation factors for the assembly of initiation complexes. However, it is currently unknown how IRES RNAs recognize initiation factors that have no endogenous RNA binding partners; in a prominent example, the IRES of encephalomyocarditis virus (EMCV) interacts with the HEAT-1 domain of eukaryotic initiation factor 4G (eIF4G). Here we report th ...[more]