Ontology highlight
ABSTRACT:
SUBMITTER: Pace JR
PROVIDER: S-EPMC5061146 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20160406 8
Itraconazole (ITZ) is an FDA-approved member of the triazole class of antifungal agents. Two recent drug repurposing screens identified ITZ as a promising anticancer chemotherapeutic that inhibits both the angiogenesis and hedgehog (Hh) signaling pathways. We have synthesized and evaluated first- and second-generation ITZ analogues for their anti-Hh and antiangiogenic activities to probe more fully the structural requirements for these anticancer properties. Our overall results suggest that the ...[more]