Middle age self-report risk score predicts cognitive functioning and dementia in 20-40 years.
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ABSTRACT: Introduction
On the basis of the proxy measures of cognitive reserve, we created a middle age self-report risk score for early prediction of dementia.Methods
We used a longitudinal population-based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments.Results
The prevalence of dementia was 10% after a mean follow-up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74-0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow-up of 39 years in the replication sample.Discussion
Self-report risk score predicted cognitive functioning and dementia risk 20-40 years later.
SUBMITTER: Vuoksimaa E
PROVIDER: S-EPMC5061466 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Middle age self-report risk score predicts cognitive functioning and dementia in 20-40 years.
Vuoksimaa Eero E Rinne Juha O JO Lindgren Noora N Heikkilä Kauko K Koskenvuo Markku M Kaprio Jaakko J
Alzheimer's & dementia (Amsterdam, Netherlands) 20160914
<h4>Introduction</h4>On the basis of the proxy measures of cognitive reserve, we created a middle age self-report risk score for early prediction of dementia.<h4>Methods</h4>We used a longitudinal population-based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments.<h4>Results</h4>The preva ...[more]
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