Ontology highlight
ABSTRACT:
SUBMITTER: Li R
PROVIDER: S-EPMC5062081 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Li Ruifeng R Liu Yifang Y Li Tingting T Li Cheng C
Scientific reports 20161013
Chromosomal rearrangement (CR) events have been implicated in many tumor and non-tumor human diseases. CR events lead to their associated diseases by disrupting gene and protein structures. Also, they can lead to diseases through changes in chromosomal 3D structure and gene expression. In this study, we search for CR-associated diseases potentially caused by chromosomal 3D structure alteration by integrating Hi-C and ChIP-seq data. Our algorithm rediscovers experimentally verified disease-associ ...[more]