Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets.
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ABSTRACT:
SUBMITTER: Georgiev H
PROVIDER: S-EPMC5062562 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets.
Georgiev Hristo H Ravens Inga I Benarafa Charaf C Förster Reinhold R Bernhardt Günter G
Nature communications 20161010
Invariant natural killer T (iNKT) cells comprise a subpopulation of innate lymphocytes developing in thymus. A new model proposes subdividing murine iNKT cells into iNKT1, 2 and 17 cells. Here, we use transcriptome analyses of iNKT1, 2 and 17 subsets isolated from BALB/c and C57BL/6 thymi to identify candidate genes that may affect iNKT cell development, migration or function. We show that Fcɛr1γ is involved in generation of iNKT1 cells and that SerpinB1 modulates frequency of iNKT17 cells. More ...[more]
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