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A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome.


ABSTRACT: The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.

SUBMITTER: Mathias RA 

PROVIDER: S-EPMC5062574 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome.

Mathias Rasika Ann RA   Taub Margaret A MA   Gignoux Christopher R CR   Fu Wenqing W   Musharoff Shaila S   O'Connor Timothy D TD   Vergara Candelaria C   Torgerson Dara G DG   Pino-Yanes Maria M   Shringarpure Suyash S SS   Huang Lili L   Rafaels Nicholas N   Boorgula Meher Preethi MP   Johnston Henry Richard HR   Ortega Victor E VE   Levin Albert M AM   Song Wei W   Torres Raul R   Padhukasahasram Badri B   Eng Celeste C   Mejia-Mejia Delmy-Aracely DA   Ferguson Trevor T   Qin Zhaohui S ZS   Scott Alan F AF   Yazdanbakhsh Maria M   Wilson James G JG   Marrugo Javier J   Lange Leslie A LA   Kumar Rajesh R   Avila Pedro C PC   Williams L Keoki LK   Watson Harold H   Ware Lorraine B LB   Olopade Christopher C   Olopade Olufunmilayo O   Oliveira Ricardo R   Ober Carole C   Nicolae Dan L DL   Meyers Deborah D   Mayorga Alvaro A   Knight-Madden Jennifer J   Hartert Tina T   Hansel Nadia N NN   Foreman Marilyn G MG   Ford Jean G JG   Faruque Mezbah U MU   Dunston Georgia M GM   Caraballo Luis L   Burchard Esteban G EG   Bleecker Eugene E   Araujo Maria Ilma MI   Herrera-Paz Edwin Francisco EF   Gietzen Kimberly K   Grus Wendy E WE   Bamshad Michael M   Bustamante Carlos D CD   Kenny Eimear E EE   Hernandez Ryan D RD   Beaty Terri H TH   Ruczinski Ingo I   Akey Joshua J   Barnes Kathleen C KC  

Nature communications 20161011


The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic  ...[more]

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