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Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.

ABSTRACT: The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed the first genome-wide association meta-analysis of ST-T-wave amplitudes in up to 37 977 individuals identifying 71 robust genotype-phenotype associations clustered within 28 independent loci. Fifty-four genes were prioritized as candidates underlying the phenotypes, including genes with established roles in the cardiac repolarization phase (SCN5A/SCN10A, KCND3, KCNB1, NOS1AP and HEY2) and others with as yet undefined cardiac function. These associations may provide insights in the spatiotemporal contribution of genetic variation influencing cardiac repolarization and provide novel leads for future functional follow-up.

SUBMITTER: Verweij N

PROVIDER: S-EPMC5062578 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.

Verweij Niek N Mateo Leach Irene I Isaacs Aaron A Arking Dan E DE Bis Joshua C JC Pers Tune H TH Van Den Berg Marten E ME Lyytikäinen Leo-Pekka LP Barnett Phil P Wang Xinchen X Soliman Elsayed Z EZ Van Duijn Cornelia M CM Kähönen Mika M Van Veldhuisen Dirk J DJ Kors Jan A JA Raitakari Olli T OT Silva Claudia T CT Lehtimäki Terho T Hillege Hans L HL Hirschhorn Joel N JN Boyer Laurie A LA Van Gilst Wiek H WH Alonso Alvaro A Sotoodehnia Nona N Eijgelsheim Mark M De Boer Rudolf A RA De Bakker Paul I W PI Franke Lude L Van Der Harst Pim P

Human molecular genetics 20160308 10

The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed the first genome-wide association meta-analysis of ST-T-wave amplitudes in up to 37 977 individuals identifying 71 robust genotype-phenotype associations clustered within 28 independent loci. Fifty-four genes were prioritized as candidates under ...[more]

PMID: 26962151

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Project description:Differentiation between ischaemic and non-ischaemic transient ST segment events of long term ambulatory electrocardiograms is a persisting weakness in present ischaemia detection systems. Traditional ST segment level measuring is not a sufficiently precise technique due to the single point of measurement and severe noise which is often present. We developed a robust noise resistant orthogonal-transformation based delineation method, which allows tracing the shape of transient ST segment morphology changes from the entire ST segment in terms of diagnostic and morphologic feature-vector time series, and also allows further analysis. For these purposes, we developed a new Legendre Polynomials based Transformation (LPT) of ST segment. Its basis functions have similar shapes to typical transient changes of ST segment morphology categories during myocardial ischaemia (level, slope and scooping), thus providing direct insight into the types of time domain morphology changes through the LPT feature-vector space. We also generated new Karhunen and Lo ève Transformation (KLT) ST segment basis functions using a robust covariance matrix constructed from the ST segment pattern vectors derived from the Long Term ST Database (LTST DB). As for the delineation of significant transient ischaemic and non-ischaemic ST segment episodes, we present a study on the representation of transient ST segment morphology categories, and an evaluation study on the classification power of the KLT- and LPT-based feature vectors to classify between ischaemic and non-ischaemic ST segment episodes of the LTST DB. Classification accuracy using the KLT and LPT feature vectors was 90% and 82%, respectively, when using the k-Nearest Neighbors (k = 3) classifier and 10-fold cross-validation. New sets of feature-vector time series for both transformations were derived for the records of the LTST DB which is freely available on the PhysioNet website and were contributed to the LTST DB. The KLT and LPT present new possibilities for human-expert diagnostics, and for automated ischaemia detection.

Dataset Information

Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.

Publications

Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.

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