Ontology highlight
ABSTRACT:
SUBMITTER: Kurdi AT
PROVIDER: S-EPMC5062600 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Kurdi Ahmed T AT Bassil Ribal R Olah Marta M Wu Chuan C Xiao Sheng S Taga Mariko M Frangieh Michael M Buttrick Thomas T Orent William W Bradshaw Elizabeth M EM Khoury Samia J SJ Elyaman Wassim W
Nature communications 20161011
RORγt is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases. Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family G protein, Rac1, regulate interleukin (IL)17A transcription and autoimmunity. Whereas Tiam1 genetic deficiency weakens IL-17A expression partially and inhibits the development of experimental autoimmune encephalomyelitis (EAE), deletion of Rac1 in T cells exhibits more robus ...[more]