Ontology highlight
ABSTRACT:
SUBMITTER: Santolini M
PROVIDER: S-EPMC5062961 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Santolini Marc M Sakakibara Iori I Gauthier Morgane M Ribas-Aulinas Francesc F Takahashi Hirotaka H Sawasaki Tatsuya T Mouly Vincent V Concordet Jean-Paul JP Defossez Pierre-Antoine PA Hakim Vincent V Maire Pascal P
Nucleic acids research 20160614 18
Myogenic regulatory factors of the MyoD family have the ability to reprogram differentiated cells toward a myogenic fate. In this study, we demonstrate that Six1 or Six4 are required for the reprogramming by MyoD of mouse embryonic fibroblasts (MEFs). Using microarray experiments, we found 761 genes under the control of both Six and MyoD. Using MyoD ChIPseq data and a genome-wide search for Six1/4 MEF3 binding sites, we found significant co-localization of binding sites for MyoD and Six proteins ...[more]