Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC5063002 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Zhang Feiran F Hammack Christy C Ogden Sarah C SC Cheng Yichen Y Lee Emily M EM Wen Zhexing Z Qian Xuyu X Nguyen Ha Nam HN Li Yujing Y Yao Bing B Xu Miao M Xu Tianlei T Chen Li L Wang Zhiqin Z Feng Hao H Huang Wei-Kai WK Yoon Ki-Jun KJ Shan Chao C Huang Luoxiu L Qin Zhaohui Z Christian Kimberly M KM Shi Pei-Yong PY Xu Mingjiang M Xia Menghang M Zheng Wei W Wu Hao H Song Hongjun H Tang Hengli H Ming Guo-Li GL Jin Peng P
Nucleic acids research 20160831 18
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function is unclear. Here we systematically profiled transcriptomes of human neural progenitor cells exposed to Asian ZIKV<sup>C</sup>, African ZIKV<sup>M</sup>, and dengue virus (DENV). In contrast to the robust global transcriptome changes induced by DENV, ZIKV has a more selective and larger impact on expression of genes involved in DNA replication and repai ...[more]