Photocontrolled Exposure of Pro-apoptotic Peptide Sequences in LOV Proteins Modulates Bcl-2 Family Interactions.
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ABSTRACT:
SUBMITTER: Mart RJ
PROVIDER: S-EPMC5063126 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Photocontrolled Exposure of Pro-apoptotic Peptide Sequences in LOV Proteins Modulates Bcl-2 Family Interactions.
Mart Robert J RJ Meah Dilruba D Allemann Rudolf K RK
Chembiochem : a European journal of chemical biology 20151120 8
LOV domains act as biomolecular sensors for light, oxygen or the environment's redox potential. Conformational changes upon the formation of a covalent cysteinyl flavin adduct are propagated through hydrogen-bonding networks in the core of designed hybrid phototropin LOV2 domains that incorporate the Bcl homology region 3 (BH3) of the key pro-apoptotic protein BH3-interacting-domain death agonist (BID). The resulting change in conformation of a flanking amphiphilic α-helix creates a light-depend ...[more]
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