Ontology highlight
ABSTRACT:
SUBMITTER: O'Sullivan S
PROVIDER: S-EPMC5063333 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20161013 10
Nilotinib and imatinib are tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). In vitro, imatinib and nilotinib inhibit osteoclastogenesis, and in patients they reduce levels of bone resorption. One of the mechanisms that might underlie these effects is an increase in the production of osteoprotegerin (OPG). In the current work we report that platelet-derived growth factor receptor beta (PDGFRβ) signaling regulates ...[more]