Unilateral Carotid Body Resection in Resistant Hypertension: A Safety and Feasibility Trial.
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ABSTRACT:
SUBMITTER: Narkiewicz K
PROVIDER: S-EPMC5063532 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
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Unilateral Carotid Body Resection in Resistant Hypertension: A Safety and Feasibility Trial.
Narkiewicz Krzysztof K Ratcliffe Laura E K LE Hart Emma C EC Briant Linford J B LJ Chrostowska Marzena M Wolf Jacek J Szyndler Anna A Hering Dagmara D Abdala Ana P AP Manghat Nathan N Burchell Amy E AE Durant Claire C Lobo Melvin D MD Sobotka Paul A PA Patel Nikunj K NK Leiter James C JC Engelman Zoar J ZJ Nightingale Angus K AK Paton Julian F R JF
JACC. Basic to translational science 20160829 5
Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body resection in 15 patients with drug-resistant hypertension. The procedure proved to be safe and feasible. Overall, no change in blood pressure was found. However, 8 patients showed significant reductions ...[more]
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