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Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus.

ABSTRACT: The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.

SUBMITTER: Deng YQ

PROVIDER: S-EPMC5063548 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus.

Deng Yong-Qiang YQ Zhang Na-Na NN Li Chun-Feng CF Tian Min M Hao Jia-Nan JN Xie Xu-Ping XP Shi Pei-Yong PY Qin Cheng-Feng CF

Open forum infectious diseases 20160830 4

The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results hav ...[more]

PMID: 27747251

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