Ontology highlight
ABSTRACT:
SUBMITTER: Gouveia A
PROVIDER: S-EPMC5063627 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Stem cell reports 20160908 4
While epigenetic modifications have emerged as attractive substrates to integrate environmental changes into the determination of cell identity and function, specific signals that directly activate these epigenetic modifications remain unknown. Here, we examine the role of atypical protein kinase C (aPKC)-mediated Ser436 phosphorylation of CBP, a histone acetyltransferase, in adult hippocampal neurogenesis and memory. Using a knockin mouse strain (CbpS436A) in which the aPKC-CBP pathway is defic ...[more]