Ontology highlight
ABSTRACT:
SUBMITTER: Sugita S
PROVIDER: S-EPMC5063629 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Sugita Sunao S Iwasaki Yuko Y Makabe Kenichi K Kamao Hiroyuki H Mandai Michiko M Shiina Takashi T Ogasawara Kazumasa K Hirami Yasuhiko Y Kurimoto Yasuo Y Takahashi Masayo M
Stem cell reports 20160915 4
There is an ongoing controversy as to whether major histocompatibility complex (MHC) matching is a solution for allogeneic stem cell transplantation. In the present study, we established retinal pigment epithelial (RPE) cells from induced pluripotent stem cells (iPSCs) in MHC homozygote donors. We observed no rejection signs in iPSC-derived RPE allografts of MHC-matched animal models without immunosuppression, whereas there were immune attacks around the graft and retinal tissue damage in MHC-mi ...[more]