Ontology highlight
ABSTRACT:
SUBMITTER: Kovalevsky A
PROVIDER: S-EPMC5063671 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kovalevsky Andrey A Blumenthal Donald K DK Cheng Xiaolin X Taylor Palmer P Radić Zoran Z
Annals of the New York Academy of Sciences 20160702 1
Acetylcholinesterase (AChE; EC 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (OP) pesticide intoxication. Catalytically inactive OP-AChE conjugates formed between the active-center serine and phosphorus of OPs can, in principle, be reactivated by nucleophilic oxime antidotes. Antidote efficacy is limited by the structural diversity of OP-AChE conjugates resulting from differences in the structure of the ...[more]