Unknown

Dataset Information

0

Pheochromocytoma in Old World Primates (Macaca mulatta and Chlorocebus aethiops).


ABSTRACT: Pheochromocytoma, a rarely reported adrenal gland neoplasm in Old World primates, was diagnosed in 5 rhesus macaques (Macaca mulatta) and 2 African green monkeys (Chlorocebus aethiops) from 3 research institutions. Age and sex were available for 6 primates. Two males and 4 females were affected, ranging in age from 9 to 31 years. All neoplasms were unilateral and, in the cases reporting the affected gland, 4 involved the right adrenal gland and 2 involved the left. Diagnosis was established by characteristic histologic features. Immunohistochemically, neoplastic cells in all cases expressed chromogranin A and met-enkephalin and were negative for melan-A and inhibin. Six of 7 tumors were positive for ?-endorphin. Pulmonary metastases were present in 2 rhesus macaques and portal vein invasion in 1 African green monkey. To the authors' knowledge, this is the first report of malignant pheochromocytoma in Old World primates.

SUBMITTER: Colgin LM 

PROVIDER: S-EPMC5063680 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pheochromocytoma in Old World Primates (Macaca mulatta and Chlorocebus aethiops).

Colgin L M A LM   Schwahn D J DJ   Castillo-Alcala F F   Kiupel M M   Lewis A D AD  

Veterinary pathology 20160518 6


Pheochromocytoma, a rarely reported adrenal gland neoplasm in Old World primates, was diagnosed in 5 rhesus macaques (Macaca mulatta) and 2 African green monkeys (Chlorocebus aethiops) from 3 research institutions. Age and sex were available for 6 primates. Two males and 4 females were affected, ranging in age from 9 to 31 years. All neoplasms were unilateral and, in the cases reporting the affected gland, 4 involved the right adrenal gland and 2 involved the left. Diagnosis was established by c  ...[more]

Similar Datasets

| S-EPMC2265124 | biostudies-literature
| S-EPMC3182701 | biostudies-literature
| S-EPMC4665013 | biostudies-literature
| S-EPMC4799702 | biostudies-literature
| S-EPMC4945616 | biostudies-literature
| PRJNA309608 | ENA
| S-EPMC7041542 | biostudies-literature
| PRJNA144771 | ENA
| PRJNA182762 | ENA
| PRJNA114523 | ENA