Evolution-development congruence in pattern formation dynamics: Bifurcations in gene expression and regulation of networks structures.

ABSTRACT: Search for possible relationships between phylogeny and ontogeny is important in evolutionary-developmental biology. Here we uncover such relationships by numerical evolution and unveil their origin in terms of dynamical systems theory. By representing developmental dynamics of spatially located cells with gene expression dynamics with cell-to-cell interaction under external morphogen gradient, gene regulation networks are evolved under mutation and selection with the fitness to approach a prescribed spatial pattern of expressed genes. For most numerical evolution experiments, evolution of pattern over generations and development of pattern by an evolved network exhibit remarkable congruence. Both in the evolution and development pattern changes consist of several epochs where stripes are

SUBMITTER: Kohsokabe T 

PROVIDER: S-EPMC5064737 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature